Liu treated 106 cases of various urinary tract infections with Ba Zheng San. The results showed that this formula demonstrated to be an effective treatment for various urinary tract infections and it also had excellent therapeutic effects on acute urinary tract infections.
8)
Yi treated 38 cases of senile urinary tract infection with modified Ba Zheng San. The formula consisted of Qu Mai (Dianthus), Bain Xu (Polygonum), Mu Tong (Akebia), Che Qian Zi (Plantain Seed), Zhi Zi (Gardenia), Du Zhong (Eucommia), Gou Qi Zi (Lycium Fruit), Shi Wei (Pyrrisia Leaf), Hua Shi (Talc), Huang Qi (Astragalus), Dang Shen (Codonopsis), and Gan Cao (Licorice). A comparison group of 32 cases was treated with Jin Qian Cao Chong Ji. One course of treatment lasted for 7 days in both groups. After 2 to 3 courses of treatment, the treatment group achieved a total effectiveness rate of 94.73% and the comparison group had a total effectiveness rate of 81.25% (P<0.01).(9)
Treating urolithiasis
Zeng treated 48 cases of urolithiasis with modified Ba Zheng San. The formula consisted of Mu Tong (Akebia), Che Qian Zi (Plantain Seed), Bian Xu (Polygonum), Qu Mai (Dianthus), Hua Shi (Talc), Zhi Zi (Gardenia), Ji Nei Jin (Membrane of Chicken's Gizzard), Hai Jin Sha (Lygodium), Da Huang (Rhubarb), Gan Cao (Licorice), and Jin Qian Cao (Plantain Herba). One dose of the formula in a decoction was administered twice a day (in the morning and in the evening). The patients were instructed to jump up and down for 30 minutes after taking the formula. One course of this treatment lasted for 7 days. The results were, 41 cases were resolved, and the remaining 7 cases improved, with a 100% total effectiveness rate.(10)
Luan treated 46 cases of urolithiasis with Ba Zheng San plus Ji Nei Jin (Membrane of Chicken's Gizzard) and Jin Qian Cao (Glechoma), and reported that 46 cases had been resolved, 27 cases had greatly improved, and the remaining 7 cases did not respond to the treatment, with a total effectiveness rate of 84.8%.(11)
Zang et al. treated 25 cases of urolithiasis with modified Ba Zheng San. The formula consisted of Mu Tong (Akebia), Che Qian Zi (Plantain Seed), Qu Mai (Dianthus), Da Huang (Rhubarb), Hua Shi (Talc), Bian Xu (Polygonum), Zhi Zi (Gardenia), Jin Qian Cao (Glechoma), Hai Jin Sha (Lygodium), Ji Nei Jin (Membrane of Chicken's Gizzard), He Tao Ren (Walnut Seed), Bai Mao Gen (Imperata), Sheng Di Huang (Rehmannia), Di Yu (Sanguissorba), Wu Yao (Lindera), and Gan Cao (Licorice). One dose of the formula in a decoction was administered daily. After treatment, all 25 cases were resolved.(12)
Treating stranguria
Wu treated 68 cases of stranguria with Ba Zheng San, which included a large-dose of Da Huang (Rhubarb). A comparison group of 30 cases was also treated with Ba Zheng San, but with Da Huang (Rhubarb) at the usual amount. For both groups, one dose of the formula in a decoction was administered daily, and one course of treatment lasted 20 for days. After these treatments, of the treatment group, 55 cases were resolved, 8 cases greatly improved, another 4 cases improved, and the remaining 1 case did not respond to the treatment, with a total effectiveness rate of 98.6%; of the comparison group, the corresponding numbers were 12, 7, 8, 3, and 90% (P<0.05).(13)
Tao treated 30 cases of male chronic stranguria with modified Ba Zheng San. The formula consisted of Hua Shi (Talc), Zhi Zi (Gardenia), Bian Xu (Polygonum), Qu Mai (Dianthus), Jin Qian Cao (Glechoma), Che Qian Cao (Plantain Herba), Mu Tong (Akebia), Da Huang (Rhubarb), Fu Ling (Hoelen), Chen Pi (Citrus Peel), Bai Zhu (Atractylodes), Hou Po (Magnolia Balk), Gan Cao (Licorice), and Deng Xin Cao (Medulla Junci). One course of treatment lasted for 14 days. The results were, 21 cases were resolved, 6 cases improved, and the remaining 3 cases did not respond to the treatment.(14)
Wang treated 62 cases of post-stranguria syndrome (such as urinary tract burning sensations and purulent secretions) with modified Ba Zheng San. The formula consisted of Bian Xu (Polygonum), Qu Mai (Dianthus), Hua Shi (Talc), Che Qian Zi (Plantain Seed), Zhi Zi (Gardenia), Mu Tong (Akebia), Da Huang (Rhubarb), and Deng Xin Cao (Medulla Junci). After treatment, 52 cases were resolved, another 6 cases improved, and the remaining 4 cases did not respond to the treatment.(15)
Treating pyelonephritis and albuminuria
In treating 70 cases of pyelonephritis, Wang et al. primarily used Ba Zheng San. Antibiotics were also administered to selected patients when appropriate. The results showed that 40 cases were resolved, 26 cases improved, and the remaining 4 cases did not respond to the treatment.(16)
Sun et al. treated 36 cases of albuminuria with modified Ba Zheng San. The formula consisted of Che Qian Zi (Plantain Seed), Mu Tong (Akebia), Qu Mai (Dianthus), Hua Shi (Talc), Zhi Zi (Gardenia), Bian Xu (Polygonum), Fu Ling (Hoelen), Huang Bai (Phellodendron), Jin Yin Hua (Lonicera Flower), Lian Qiao (Forsythia), Bai Hua She She Cao (Oldenlandia), Deng Xin Cao (Melluda Junci), Gan Cao (Licorice), and Da Huang (Rhubarb). For patients who were also suffering from edema, Ze Xie (Alisma) and Bai Zhu (Atractylodes) were added and for patients who were also suffering from hematuria, Mao Gen (Imperata), Da Ji (Cirsium), and Xiao Ji (Field Thistle) were added. The results showed that 3 cases were resolved, another 6 cases greatly improved, and the remaining 27 cases improved.(17)
Treating miscellaneous diseases
Guan et al. treated 53 cases of post-surgery irritable urinary tract syndrome with modified Ba Zheng San. The formula consisted of Mu Tong (Akebia), Qu Mai (Dianthus), Bian Xu (Polygonum), Che Qian Zi (Plantain Seed), Zhi Zi (Gardenia), Da Huang (Rhubarb), Gan Cao (Licorice), Deng Xin Cao (Medulla Junci), and Hua Shi (Talc). After 2 to 7 doses, a treatment effectiveness evaluation concluded that the treatment was highly effective in 38 cases, moderately effective in another 9 cases, and ineffective in the remaining 6 cases, with a total effectiveness rate of 88.7%.(18)
Cheng treated 46 cases of sperm hypoactivity with modified Ba Zheng San. The formula consisted of Mu Tong (Akebia), Zhi Mu (Anemarrhena), Huang Bai (Phellodendron), Che Qian Zi (Plantain Seed), Da Huang (Rhubarb), Niu Xi (Achyranthes), etc. The treatment was effective in 91.3% of the patients.(19)
Wu et al. treated 36 cases of distention during pregnancy with modified Ba Zheng San, and reported that the treatment was effective in all of the patients.(20)
Liu et al. treated 100 cases of pelvic inflammation with modified Ba Zheng San. The formula consisted of Qu Mai (Dianthus), Bian Xu (Polygonum), Hua Shi (Talc), Che Qian Zi (Plantain Seed), Zhi Zi (Gardenia), Mu Dan Pi (Moutan), Chuan Lian Zi (Melia), Bai Jiang Cao (Thlaspi), Jin Yin Hua (Lonicera Flower), Pu Gong Ying (Dandelion), and Da Huang (Rhubarb). The results showed that 84 cases were resolved, 12 cases improved, and the remaining 4 cases did not respond to the treatment, with a total effectiveness rate of 96%.(21)