Bai Shao - Chinese HerbsPaeoniae Alba Radix, White Peony Root
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| Dosage |
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Decoction: 5-12g, large dosages can use up till 15-30g.
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| Toxicity |
LD50 (mice): 81g/kg (oral/decoction), 125mg/kg (i.p./TGP), 3.53g/kg (paeoniflorin).( 1),( 2),( 3) |
| Chemical Composition |
Paeoniflorin; Albiflorin; Oxypaeoniflorin; Paeonin; Benzoylpaeoniflorin; Hydroxypaeoniflorin; Galloylpaeoniflorin; Lactoflorin; Paeonilactone A, B, C; b-sitosterol; Daucosterol; Z-1s, 5R-b-pinen-10-yl-b-vicianoside; 1, 2, 3, 6-tetra-O-galloyl-b-D-glucose;
1, 2, 3, 4, 6-penta-O-galloyl-b-D-glucose;
Catechin;
Benzoic acid;
Paeonol.( 4),( 5),( 6),( 7)
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| Inorganic Chemicals |
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Ni, Fe, Cu, Mn, Cr
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| Precautions |
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Individual use of the herb is contraindicated for cold syndromes of the deficiency type. The herb is incompatible with Li Lu (black falsehellebore root and rhizome).
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| Pharmacology |
Total glycosides of peony (TGP), paeoniflorin (PF), and TGP minus PF all have a concentration-dependent effect of increasing the low spleen lymphocyte proliferation in rats of adjuvant arthritis (all with a bell-shaped dose-effect relationship) and all can inhibit the peritoneal phagocytes' overproduction of IL-1 in rats of adjuvant arthritis (all with a reversed bell-shaped dose-effect relationship). In both instances, the effect of TGP is the most pronounced of the three.( 8) Administered to rats with adjuvant arthritis, TGP can not only inhibit foot swelling, they can also lower the elevated levels of MDA, NO2, and TNF, while raising the sagged activities of SOD, GSH-Px.( 9) Experiments show that Bai Shao has a dosage-dependent inhibitory effect on hepatic lipid peroxidation.( 10) Research shows that Bai Shao can directly act on the intestines, increasing mucus secretion in the large intestines, enhancing movement, and increasing the water content in both the small and large intestines.( 11) Experiments show that TGP of relatively high concentrations can significantly increase the activity of Ca+|-Mg+|-ATPase and Na+|-K+|-ATPase, and decrease the concentration of cytoplasmic free calcium ions.( 12) TGP can cause vasodilation in isolated rabbit ears.( 13) They can also significantly lengthen mice's survival time from oxygen deprivation under normal pressure. They can improve the cardiac function of rabbits of pituitin-induced myocardial ischemia. These effects are dosage-dependent.( 14) |
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References
This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.
©2000-2008 ADCCG, Inc. All Rights Reserved.