Bing PianBorneolum, Borneol
| Dosage |
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Internal administration: 0.15 to 0.3g, in pill or powder form. Do not used in decoction form.
External use: Appropriate doses ground into powder for topical application or making into paste then applied.
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| Toxicity |
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LD50 of bornyl, isobornyl, and borneol syntheticum by oral administration is 2879, 2269, and 2507mg/kg.
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| Chemical Composition |
D-bornyl;
Isobornyl;
b-elemene;
Caryophyllene;
Triterpenoids;
Asoleamolic acid;
Maizhuzi acid;
Asiatic acid;
Boryl hydrinone;
Boryl hydrindiolone;
Cineole;
L-borneol;
Sesquiterterpenol;
Isoborneol. ( 1),( 2),( 3),( 4)
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| Inorganic Chemicals |
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It also contains traces of the element Pb.
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| Precautions |
Pregnant women and those deficient in qi and blood should use with caution. An allergic reaction to Bing Pian has been reported in oral and external administrations.( 5),( 6),( 7),( 8) |
| Pharmacology |
Intra-peritoneal injections of Bing Pian at doses of 1/4, 1/8, and 1/16 of LD50 were administered to mice at different stages in pregnancy. It distinctly induced abortion in intermediate and advanced stages of pregnancy in mice. It has no significant effect in the early stages of pregnancy.( 9) Liang Mei Rong observed the effects of Bing Pian on the blood-brain barrier by examining the intensity of coloration in the brain tissue after administering Evan's Blue. It was found that Bing Pian pills could increase the intensity of the blue stained brain tissue in rabbits and rats. This suggests that Bing Pian may increase the permeability of the blood-brain barrier.( 10) It was found that the gentamicin concentration in brain tissue increased after administering Bing Pian to rats.( 11) It was demonstrated by Xu Wei that the half-life of sulfadiazine in rats was largely prolonged after gastrolavage of Bing Pian (10% Bing Pian in paraffin oil 15ml/kg), and the sulfadiazine concentrations in the rat brain tissue increased.( 12) Footpad swelling in mice, induced by egg albumin was markedly suppressed by borneal and isoborneal. Isoborneal was also effective in reducing cedar-oil generated swelling in mouse ear lobes.( 13) In guinea pigs, Bing Pian acted as strong anti-inflammatory and analgesic agents for burns caused by a laser.( 14) Experiments showed that Bing Pian promoted permeability in the corneal epithelium of rabbits. Cultured corneal epithelial cells were divided into two comparison groups and one experimental group. Sequence parameters arrangements of membrane phospholipid molecules in both groups were examined using the electron spinning resonance method. The sequence parameters of the two control groups and the experimental group were 0.711±0.024, 0.717±0.018, and 0.743±0.039, respectively. The differences between the experimental group and the two control groups were significant (P<0.05). This suggests that the effects of Bing Pian in promoting permeability are related to its action on the sequence arrangement of phospholipid molecules of the corneal epithelial cell membrane.( 15) Zhao Xiao Yang studied the effects of Bing Pian on eight types of mycosis. It was shown that Bing Pian is relatively potent against microsporum, Hormodendrum pedrosoi, and sporotrichum. It could suppress the growth of corynebactrium minutissimum at a 5% concentration and sporocytic at a 10% concentration. It suppressed the growth of aspergillus by 10%.( 16) Clinical studies showed that the minimal inhibitory concentration was 5% to inhibit Aspergillus Niger isolated from the exudate of the external auditory canal and other mycosis. The minimal anti-fungal concentration of Bing Pian was 10%. The changes in ultramicroscopic cellular structures were studied using electron microscopy. It was shown that Bing Pian damaged the cellular structure of mycosis, resulting in lysis and death of the mycosis, thereby showing the antimycotic and sporicidal effects of borneol.( 17) |
References
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