Gui Zhi Fu Ling Wan Georgia

Effects on C-fos gene expression of cerebral tissue after re-perfusion following cerebral ischemia: An experimental study has confirmed that Gui Zhi Fu Ling Wan plus Chuan Xiong (Cnidium) and Ze Xie (Alisma) can effectively inhibit the C-fos gene expression of cerebral tissue after re-perfusion following cerebral ischemia.(2)

Alleviating effect on ischemic brain injury: By studying the effects on the level of Ca ²⁺ and amino acids in the process of re-perfusion following cerebral ischemia, it was shown that modified Gui Zhi Fu Ling Wan has an alleviating effect on ischemic brain injury.(3)

Effects on lipid peroxide (LPO), superoxide dismutase (SOD), and immune function of red blood cells in experimental senile hyperlipidemia: Gui Zhi Fu Ling Wan can increase the activity of SOD (superoxide dismutase) and the garland rate of C3b receptor of red blood cells (RBC-C3bR) in guinea pigs with senile hyperlipidemia, and reduce the LPO levels of the immune compound of red blood cells (RBC-IC).(4)

Effects on free radicals after cerebral ischemia: Gui Zhi Fu Ling Wan plus Chuan Xiong (Cnidium) and Ze Xie (Alisma) can increase SOD in red blood cells, cerebral tissue, and mitochondrion of rats after cerebral ischemia and re-perfusion. It can also reduce MDA levels in red blood cells in plasma, cerebral tissue, and cellular organelles of rats after cerebral ischemia and re-perfusion. The formula was confirmed as to having strong effects on resisting free radicals.(5)

Treating periappendicular abscess
Gu Yu Feng used modified Gui Zhi Fu Ling Wan to treat periappendicular abscess. The modified formula consisted of Gui Zhi (Cinnamon Twig), Chi Shao (Peony Red), Mu Dan Pi (Moutan), Tao Ren (Peach Seed), Fu Ling (Poria), Bai Hua She She Cao (Oldenlandia), Bai Jiang Cao (Thlaspi), and Niu Xi (Achyranthes Root). The ingredients were modified according to individual's symptoms. One dose of the formula in a decoction was administered daily. 33 cases were treated from 10 to 40 days. After treatment, 30 cases were resolved, and 3 cases did not respond to the treatment. The symptom of abdominal pain was alleviated to different extents, body temperature was normal, stool was not dry, and exudate from incision was reduced.(7)

Treating hyperplasia of the prostate
Cui Zhi Min used modified Gui Zhi Fu Ling Tang to treat hyperplasia of the prostate. The modified formula contained Ju He (Tangerine Seed), Niu Xi (Achyranthes Root), Hai Zao (Sargassum), Tu Bie Cong (Ground Beetle), and Huang Qi (Astragalus Root). The ingredients were modified according to each patient's symptoms. One dose of the formula in a decoction was administered daily. The results showed that after treatment on 116 cases in a group from 15 to 45 days, 38 cases were resolved, 69 cases showed some improvement, and the remaining 9 cases did not respond to the treatment. The total effectiveness rate was 93.1%.(8)

Treating hysteromyoma
Wang Hua, et al. used modified Gui Zhi Fu Ling Tang to treat hysteromyoma. The modified formula contained Gui Zhi (Cinnamon Twig), Mu Dan Pi (Moutan), Fu Ling (Poria), Tao Ren (Peach Seed), Chi Shao (Peony Red), and E Zhu (Zedoary). The formula was modified according to individual's symptoms. One dose of the formula in decoction was administered daily. One month constituted one course of treatment. The results showed that after treatment on 75 cases in the treatment group, 15 cases were resolved, 21 cases had significantly improved, 34 cases improved slightly, and the remaining 5 cases did not respond to the treatment. The total effectiveness rate was 93.3%.(9)