All Topics > Health > Traditional Chinese Medicine Herb > Mu Dan Pi >

Mu Dan Pi Connecticut

Local Companies

Western New England Institute for Psychoanalysis
203 562-2103
255 Bradley Street
New Haven, CT

Downtown Health and Racquet Club
203-787-6501
230 George Street
New Haven, CT

Physique Plus Fitness Center Ltd.
203-272-0014
1303 Highland Ave
Cheshire, CT

Total Transformations, LLC
(860) 986-4804
New Britian Ave
West Hartford, CT

No Boundaries Fitness
860-710-1385
private
Taftville, CT

Spa at Norwich Inn
(800) 275-4772
607 West Thames Street
Norwich, CT

Fitness & Yoga for Women/Sound Mind & Body
203-878-9642
213 Cherry Street
Milford, CT

Oxford Health Plan
(203) 459-6993
48 Monroe Turnpike
Trumbull, CT

Maximum Health & Fitness
203-284-9700
47 Capital Drive
Wallingford, CT

World Gym
203-269-6879
340 Quinnapiac Street
Wallingford, CT

Mu Dan Pi
Moutan Radicis Cortex, Moutan

Dosage
6~9g for oral decoction, or for pill and powder.

Toxicity
LD50 (mice/peritoneal injection): 735mg/kg (paeonol oil); 6.9mg/kg (paeonol sodium sulfonate).(1)

Chemical Composition
Paeoniflorin; Oxypaeoniflorin; Benzoylpaeoniflorin; Benzoyloxy-paeoniflorin; Paeonol; Paeonoside; Paeonolide; Aplopaeonoside; 2Â£-3-di-hydroxy-4-methoxyacetophenone; 3-hydroxy-4-methoxyacetophenone; 1Â£-2Â£-3Â£-4Â£-6-pentagalloylglucose.(2)

Precautions
Patients with the following conditions should avoid using this herb: blood deficiency syndromes, cold of the deficiency type, hypermenorrhea, or pregnancy. There has been one report of side-effects: when 5% Mu Dan Pi cream was used to treat acute localized eczema, local red spots, itch, and burning sensation were experienced by some patients.(3)

Pharmacology

Analgesic effect

Experiments show that paeonol has a significant analgesic effect on mice. Paeonol was administered to mice via subcutaneous injection for 7 days. Hot plate test was used to measure the pain threshold. The results suggested that paeonol induced analgesia causes no drug resistance. Both tail-erection reaction test and jumping reaction test showed negative results, when mice were given paeonol via subcutaneous injection. Hot plate test showed that the analgesic effect of paeonol can not be reversed by naloxone.(4)

Anti-inflammatory effects

In mice, dimethylbenzene-induced auricle inflammation can be inhibited effectively by gastrolavaging Mu Dan Pi decoction at dosages 10g/kg, 20g/kg, or 40g/kg. Also, feet swelling that is caused by carrageenin, formaldehyde, or egg white can be significantly inhibited by intraperitoneal injection of Mu Dan Pi at 15g/kg or 30g/kg. The effects are dosage-dependent.(5)

Effects on the blood system

Total glycoside of Mudanpi (TGM) can protect RBC, inhibit platelet aggregation, increase the cAMP level in blood platelets, counteract atheroscleorsis, and promote local microcirculation.(6),(7),(8),(9) It can inhibit H202-induced hemolysis. Low concentrations of TGM inhibits osmotic hemolysis, while in higher concentration (100mg.L-1), it promotes osmotic hemolysis. TGM inhibits H202-induced consumption of reduced glutathione in RBC and the production of lipide peroxide. Experiments show that paeonol can inhibit platelet aggregation both in vivo and in vitro.

Liver-protective effect

Experiments show that in mice with carbon tetrachloride or ethanol-induced liver damages, TGM (20mg/kg-1) can significantly inhibit the increase in serum SGPT and the generation of lipide peroxid.(10)

Effect on immunological functions

Paeonol, given by i.g. 200mg/kg for 5 consecutive days, can reduce the weight of immune organs in mice, increase carbon clearance, relieve delayed hypersensitivity, and decrease the hemolysin antibody level in the spleen. In mice, it can significantly inhibit lymphocyte proliferation in the spleen that is induced by LPS and by Con A in sub-suitable concentrations. Paeonol (50Â¦Ìg/ml) can also, in vitro, significantly inhibit the proliferation of mice's experimental spleen lymphocytes.(11) In low concentrations (10-15mg/kg), paeonol functions to increase the percentage of lymphocyte with positive (-ANAE and promotes the release of leukocyte migration inhibitory factor in peripheral circulation, thereby improving the cellular immunity. Furthermore, it could promote the phagocytosis of peripheral neutrophil on Staphylococcus aureus, thereby enhancing nonspecific immunity.(12)

Effects on the cardiovascular system

Paeonol has a significant and immediate inhibitory effect on delayed I K, I Na, I Ca T, and I Ca L. The effect can be observed within 1 minute of administration, and it shows a dose-effect correlation and a good reversibility.(13) When paeonol was given by intraperitoneal in a dose of 160.80mg/kg for 7 days to rats with myocardial reperfusion injury, it showed significant anti-arrhythmic effect on the animals. Its mechanism is probably related to anti-oxidation free radicals.(14)

Other actions

Experiments show that paeonol can slow down the gaining of body weight in animals. The body temperature of normal mice was decreased by 2.9Â¡æ within 30 minutes after the peritoneal injection of paeonol (200mg/kg). It has an antipyretic effect on the fever induced by choler-typhoid-paratyphoid vaccine.(15)

References

Wang Qi Bao, et al. Journal of Chinese Materia Medica. 1983;(10):26.
Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
Tang Hong Shan. Journal of Chinese Materia Medica. 1983;24(10):19.
Liu Xue Jun, et al. Chinese Pharmacology Bulletin. 1993;9(6):464-467.
Wu Guan Zhong,et al. Journal of University of Pharmacology of China. 1990;21(4).
Gao Ben Po, et al. China Journal of Pharmacology. 1992;8(3):202-205.
Dai Ming, et al. China Journal of Chinese Medicine, 1999;24(8):488-490.
Shi Ling, et al. China Journal of Pharmacology. 1988;9(6):555.
Ye Zhi Yi, et al. China Journal of Blood Rheology. 1999;9(3):137-138.
Dai Li Ming, et al. China Journal of Pharmacology. 1994;10(1):58-59.
Wang Xing Wang, et al. Journal of Pharmacology and Clinical Application of TCM. 1992;8(2):29-30.
Li Feng Chun, et al. China Journal of Integrated Medicine. 1994;14(1):37-38.
Hu Qian, et al. Journal of Physiology. 1994;46(6):575-580.
Zhang Guang Qin, et al. Journal of University of Pharmacology of China. 1997;28(4):225-227.
Wang Qi Bao, et al. Journal of Chinese Materia Medica. 1983;(10):26.

This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.

Featured Local Company

Western New England Institute for Psychoanalysis

203 562-2103
255 Bradley Street
New Haven, CT
http://www.wneps.org

Read more about Mu Dan Pi

- A Brain In Belly Connecticut

It turns out that these slang phrases actually have a solid, scientific basis. Medical research has proven that there is a second brain in the body and it's located in the belly.

- How to stay healthy during flu season Connecticut
- 10 warning signs every parent must know Connecticut
- "B" Vitamins Connecticut
- 10 Tips for Healthy Living Connecticut
- Common Cold: Fact or Myth Connecticut
- 3 Steps To Great Abdominal Strength Connecticut
- 7-Keto Dehydroepiandrosterone (DHEA) Connecticut
- 4 Tips For Anchoring Connecticut
- 5-Hydroxytryptophan (5-HTP) Connecticut

Regional Articles

- Mu Dan Pi Ansonia CT
- Mu Dan Pi Bethel CT
- Mu Dan Pi Branford CT
- Mu Dan Pi Bridgeport CT
- Mu Dan Pi Bristol CT
- Mu Dan Pi Cheshire CT
- Mu Dan Pi Danbury CT
- Mu Dan Pi East Hartford CT
- Mu Dan Pi East Haven CT
- Mu Dan Pi Enfield CT
- Mu Dan Pi Glastonbury CT
- Mu Dan Pi Greenwich CT
- Mu Dan Pi Groton CT
- Mu Dan Pi Guilford CT
- Mu Dan Pi Hamden CT
- Mu Dan Pi Hartford CT
- Mu Dan Pi Manchester CT
- Mu Dan Pi Meriden CT
- Mu Dan Pi Middletown CT
- Mu Dan Pi Milford CT
- Mu Dan Pi Naugatuck CT
- Mu Dan Pi New Britain CT
- Mu Dan Pi New Canaan CT
- Mu Dan Pi New Haven CT
- Mu Dan Pi New London CT
- Mu Dan Pi Newington CT
- Mu Dan Pi North Haven CT
- Mu Dan Pi Norwalk CT
- Mu Dan Pi Norwich CT
- Mu Dan Pi Plainville CT
- Mu Dan Pi Ridgefield CT
- Mu Dan Pi Rocky Hill CT
- Mu Dan Pi Shelton CT
- Mu Dan Pi Simsbury CT
- Mu Dan Pi South Windsor CT
- Mu Dan Pi Southbury CT
- Mu Dan Pi Southington CT
- Mu Dan Pi Stamford CT
- Mu Dan Pi Storrs Mansfield CT
- Mu Dan Pi Stratford CT
- Mu Dan Pi Torrington CT
- Mu Dan Pi Trumbull CT
- Mu Dan Pi Vernon Rockville CT
- Mu Dan Pi Wallingford CT
- Mu Dan Pi Waterbury CT
- Mu Dan Pi West Hartford CT
- Mu Dan Pi West Haven CT
- Mu Dan Pi Westport CT
- Mu Dan Pi Wethersfield CT
- Mu Dan Pi Willimantic CT
- Mu Dan Pi Wilton CT
- Mu Dan Pi Windsor CT
- Mu Dan Pi Winsted CT
- Mu Dan Pi Wolcott CT

- A Brain In Belly Connecticut

It turns out that these slang phrases actually have a solid, scientific basis. Medical research has proven that there is a second brain in the body and it's located in the belly.

Related Local Events

Health & Wellness Council
Dates: 12/22/2009 - 12/22/2009
Location: Chamber Office
Glastonbury, CT
View Details

Health & Wellness Council
Dates: 11/24/2009 - 11/24/2009
Location: Chamber Office
Glastonbury, CT
View Details

Chamber Health Care Open Forum - Understanding YOUR HealthCare
Dates: 11/19/2009 - 11/19/2009
Location: Bloomfield Town Hall - Council Chambers
Bloomfield, CT
View Details

Chamber Health Care Open Forum - Understanding YOUR HealthCare
Dates: 10/29/2009 - 10/29/2009
Location: Bloomfield Town Hall - Council Chambers
Bloomfield, CT
View Details

Discover: Peace of Mind & Freedom of Movement Through Yoga
Dates: 10/29/2009 - 10/29/2009
Location: Acton Public Library
Old Saybrook, CT
View Details

Advertising	Food & Beverage	Nightlife
Business Services	Franchise	Online Database
Career	Health	Pets
Cars	Holidays	Real Estate Resources
Computer Hardware	Home Appliances	Retail & Consumer Services
Construction	Home Electronics	Software
Education	Home Services	Technology
Entertainment	Industrial Goods & Services	Telecommunications
Environmental	Insurance	Trade Shows
Family	Internet	Travel
Fashion	Legal	Weddings
Financial Services	Miscellaneous	World History

Advertising	Family	Home Services	Real Estate Resources
Business Services	Fashion	Industrial Goods & Services	Retail & Consumer Services
Career	Financial Services	Insurance	Software
Cars	Food & Beverage	Internet	Technology
Computer Hardware	Franchise	Legal	Telecommunications
Construction	Health	Miscellaneous	Trade Shows
Education	Holidays	Nightlife	Travel
Entertainment	Home Appliances	Online Database	Weddings
Environmental	Home Electronics	Pets	World History