Omega-3 Fatty Acids

In the late 1970s, scientists learned that the native Inuits in Greenland, who consumed a diet very high in omega-3 fatty acids, had surprisingly low rates of heart attacks.

Omega-3 Fatty Acids - Dietary Supplements

Natural Health Information that is accurate, objective, science-based and represents the current state of research is the most sought-after information category today. Natural Health Information On Demand, NHIOndemand, is the leading source for this valuable science-based natural health information.
©2000-2009 CCG, Inc. All Rights Reserved.
Introduction
In the late 1970s, scientists learned that the native Inuits in Greenland, who consumed a diet very high in omega-3 fatty acids, had surprisingly low rates of heart attacks. Since that time thousands of scientific studies have evaluated the multiple ways that omega-3 fatty acids promotes not only cardiovascular health, but also the healthy functioning of many other biological activities. Many Americans don't get enough of it in their diets. One reason is that omega-3 oils are very susceptible to spoilage and so many food manufacturers remove it to keep products fresh. Another reason is that omega-3 oils mostly come from cold water fish and wild game- something most Americans don't eat in great quantities.

Flaxseed oil is another good source of omega-3. Other sources include chia, rapeseed, soybeans, alfalfa, and walnuts. In most cases, however, people are not able to consume adequate amounts of omega-3 from dietary sources and physicians often recommend supplementation.

Omega-3 refers to a group or "family" of unsaturated fatty acids. The first fatty acid in this group is named alpha linolenic acid or just linolenic acid, and sometimes it is just called omega-3. Linolenic acid cannot be made in the body and therefore, it is classified as an essential fatty acid and must be obtained from either the diet or in supplement form. The other two fatty acids in the omega-3 family are named eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The body can manufacture EPA and DHA by conversions from linolenic acid.

Dosage Info
Dosage Range
Alpha linolenic acid (omega-3): 1-2 tablespoonsful daily.

Fish oils (EPA and DHA): 500-2,000mg daily.

Most Common Dosage
Alpha linolenic acid (omega-3): 1 tablespoonful daily.

Fish oils (EPA and DHA): 1.2 grams of EPA and DHA or 3-4 grams of fish oil.

Dosage Forms
Alpha linolenic acid (omega-3): oil in gelatin capsules and in oil such as flaxseed oil; EPA and DHA: fish oils in gelatin capsules.
Interactions and Depletions
Interactions
Reported Uses
Omega-3 fatty acids are one of the primary structural components in cell walls and membranes throughout the body. They are also instrumental in regulating inflammation, blood pressure and thickness, hormone production, and the activities of the immune and central nervous systems. Omega-3 fatty acids are important for infants (and a developing fetus) for proper development of the brain and retina of the eyes.

There are many clinical applications for omega-3. Studies suggest that Attention Deficit Hyperactivity Disorder (ADHD) may be linked to omega-3 deficiency.(1),(2) Deficiencies have also been found in people who have allergies, asthma, chronic bronchitis and skin disorders like eczema and psoriasis.(3),(4),(5),(6),(7),(8) Omega-3 supplementation during pregnancy reduced the risk of eczema.(9) Supplementation with omega-3 fatty acids reduced asthma symptoms in children with moderate asthma.(10) It has been reported that higher intake of omega-3 fatty acids and fish reduces the risk of developing age-related macular degeneration.(11),(12),(13)

Omega-3 may also be a preventative measure for many major illnesses. Researchers think omega-3 can help prevent breast, prostate, and colon cancers.(14),(15),(16) Postoperative cancer patients supplemented with omega-3 experienced improved liver and pancreas function.(17) New preliminary research shows that omega 3 could be beneficial for cystic fibrosis, type 2 diabetes, and inflammatory bowel disease.(18),(19),(20) Researchers were able to establish that the highest intake of omega-3 fatty acid actually reduced the risk of developing ulcerative colitis by 77 percent.(21)

Omega-3 fatty acids can support cardiovascular health by lowering blood pressure, relaxing blood vessels and lowering cholesterol levels.(22),(23),(24),(25),(26) Dietary intake of omega-3 fatty acids reduced inflammation and endothelial activation, which may help prevent cardiovascular disease.(27) Taking 3 to 5 grams of omega-3 fatty acids per day can decrease elevated serum triglycerides as much as 50%.(28) Results of a recent study in Italy reported that patients taking 850 milligrams per day of omega-3 fatty acids had a lower rate of death related to heart conditions than those who were not taking the fatty acid.(29)

Omega-3 may also decrease inflammation(30) and reduce pain for sufferers of rheumatoid arthritis.(31),(32) Deficiencies of omega-3 in the United States as well as other countries may also be linked to depression.(33),(34) A study revealed that omega-3 proved to be beneficial by improving symptoms of depression in menopausal women.(35) Pregnant women who consumed more fish (omega-3 fatty acids) had fewer depressive symptoms in comparison to pregnant women who consumded less fish.(36) Omega 3 has also shown possible beneficial effects for other mental disorders as well.(37),(38)

Children with verbal apraxia (neurologically based motor planning speech disorder common in autism spectrum disorders) were treated with vitamin E and omega-3. All of the families involved reported significant improvements in many areas including speech, imitation, coordination, eye contact, behavior, sensory issues and development of pain sensation. Supplementation with vitamin E and omega-3 could be beneficial to children with autism and verbal apraxia.(39)

Toxicities & Precautions
Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.
Introduction
Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.
General
This dietary supplement is considered safe when used in accordance with proper dosing guidelines.

Omega-3 fatty acids are extremely susceptible to damage from free radicals. It is recommended that the antioxidants vitamin E, vitamin C and selenium be taken in concert with omega-3s.(40),(41)

Care should be taken to minimize exposure of omega-3 fatty acids to heat, light, and oxygen. If flaxseed oil is used, refrigerate it to prevent it from becoming rancid.

Pregnancy/Breast-Feeding
To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Yet little is known about the use of this dietary supplement while pregnant or breast-feeding. Therefore, it is recommended that you inform your healthcare practitioner of any dietary supplements you are using while pregnant or breast-feeding.
Age Limitations
To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Since young children may have undiagnosed allergies or medical conditions, this dietary supplement should not be used in children under 10 years of age unless recommended by a physician.
Links

Content provided by NHI OnDemand, the trusted online source of current natural health & wellness information.

References
  1. View Abstract:  Stevens L, Zentall SS, Deck JL. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr. 1995;62:761-768.
  2. View Abstract:  Colter AL, et al. Fatty acid status and behavioural symptoms of Attention Deficit Hyperactivity Disorder in adolescents: A case-control study. Nutr J. Feb2008;7(1):8.
  3. View Abstract:  Galland L. Increased Requirements for Essential Fatty Acids in Atopic Individuals: A Review with Clinical Descriptions. J Am Coll Nutr. 1986;5(2):213-28.
  4. View Abstract:  Masuev KA. The Effect of Polyunsaturated Fatty Acids of the Omega-3 Class on the Late Phase of the Allergic Reaction in Bronchial Asthma Patients. Ter Arkh. 1997;69(3):31-33.
  5. View Abstract:  Isseroff RR. Fish Again for Dinner! The Role of Fish and other Dietary Oils in the Therapy of Skin Disease. J Am Acad Dermatol. Dec1988;19(6):1073-80.
  6. View Abstract:  Oddy WH, de Klerk NH, Kendall GE, Mihrshahi S, Peat JK. Ratio of omega-6 to omega-3 fatty acids and childhood asthma. J Asthma. 2004;41(3):319-26.
  7. View Abstract:  Burns JS, et al. Low dietary nutrient intakes and respiratory health in adolescents. Chest. Jul2007;132(1):238-45
  8. View Abstract:  Koch C, et al. Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial. Br J Dermatol. Apr2008;158(4):786-92
  9. View Abstract:  Furuhjelm C, et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr. Jun2009
  10. View Abstract:  Biltagi MA, et al. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. Apr2009;98(4):737-42
  11. View Abstract:  Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. Nov1994;91(23):10771-8.
  12. View Abstract:  Chong EW, et al. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. Arch Ophthalmol. Jun2008;126(6):826-33
  13. View Abstract:  Augood C, et al. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. Am J Clin Nutr. Aug2008;88(2):398-406
  14. View Abstract:  Bagga D, et al. Dietary Modulation of Omega-3/Omega-6 Polyunsaturated Fatty Acid Ratios in Patients with Breast Cancer. J Natl Cancer Inst. Aug1997;89(15):1123-31.
  15. View Abstract:  Pandalai PK, et al. The Effects of Omega-3 and Omega-6 Fatty Acids on in Vitro Prostate Cancer Growth. Anticancer Res. Apr1996;16(2):815-20.
  16. View Abstract:  Leitzmann MF, Stampfer MJ, Michaud DS, et al. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr. Jul2004;80(1):204-16.
  17. View Abstract:  Heller AR, Rossel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative cancer patients. Int J Cancer. Sep2004;111(4):611-6.
  18. View Abstract:  De Vizia B. Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. J Parenter Enteral Nutr. 2003 Jan-Feb;27(1):52-7.
  19. View Abstract:  Jain S. Effects of low-dose omega-3 fatty acid substitution in type-2 diabetes mellitus with special reference to oxidative stress--a prospective preliminary study. J Assoc Physicians India. 2002 Aug;50:1028-33.
  20. Belluzzi A. N-3 fatty acids for the treatment of inflammatory bowel diseases. Proc Nutr Soc. 2002 Aug;61(3):391-5.
  21. View Abstract:  Hart AR. Linoleic Acid, a Dietary N-6 Polyunsaturated Fatty Acid, and the Aetiology of Ulcerative Colitis - A European Prospective Cohort Study. GUT. Jul2009
  22. View Abstract:  Kinsella JE, et al. Dietary n-3 Polyunsaturated Fatty Acids and Amelioration of Cardiovascular Disease: Possible Mechanisms. Am J Clin Nutr. Jul1990;52(1):1-28.
  23. View Abstract:  Garg ML, et al. Alpha-linolenic Acid and Metabolism of Cholesterol and Long-chain Fatty Acids. Nutrition. Jun1992;8(3):208-10.
  24. View Abstract:  Knapp HR, et al. The Antihypertensive Effects of Fish Oil. A Controlled Study of Polyunsaturated Fatty Acid Supplements in Essential Hypertension. N Engl J Med. Apr1989;320(16):1037-43.
  25. View Abstract:  Harris WS, Park Y, Isley WL. Cardiovascular disease and long-chain omega-3 fatty acids. Curr Opin Lipidol. 2003 Feb;14(1):9-14.
  26. View Abstract:  Laidlaw M, Holub B. Effects of supplementation with fish oil-derived n-3 fatty acids and gamma-linolenic acid on circulating plasma lipids and fatty acid profiles in women. Am J Clin Nutr. 2003 Jan;77(1):37-42.
  27. View Abstract:  Lopez-Garcia E, Schulze MB, Manson JE, et al. Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr. Jul2004;134(7):1806-11.
  28. View Abstract:  O'Keefe JH, Harris WS. From Inuit to implementation: omega-3 fatty acids come of age. Mayo Clin Proc. Jun2000;75(6):607-14.
  29. View Abstract:  O'Keefe JH, Harris WS. From Inuit to implementation: omega-3 fatty acids come of age. Mayo Clin Proc. Jun2000;75(6):607-14.
  30. View Abstract:  Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc. 2002 Aug;61(3):345-58.
  31. View Abstract:  Geusens P, et al. Long-term Effect of Omega-3 Fatty Acid Supplementation in Active Rheumatoid Arthritis. A 12-month, Double-blind, Controlled Study. Arthritis Rheum. Jun1994;37(6):824-29.
  32. View Abstract:  Cleland LG, Proudman SM, Hall C, et al. A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. Lipids. Apr2003;38(4):419-24.
  33. View Abstract:  Hibbeln JR, et al. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am j Clin Nutr. Jul1995;62(1):1-9.
  34. View Abstract:  Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MM. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr. Jul2003;78(1):40-6.
  35. View Abstract:  Lucas M, et al. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Am J Clin Nutr. Feb2009;89(2):641-51
  36. View Abstract:  Golding J, et al. High Levels of Depressive Symptoms in Pregnancy With Low Omega-3 Fatty Acid Intake From Fish. Epidemiology. Jul2009;20(4):598-603
  37. View Abstract:  Emsley R. Randomized, placebo-controlled study of ethyl-eicosapentaenoic acid as supplemental treatment in schizophrenia. Am J Psychiatry. 2002 Sep;159(9):1596-8.
  38. View Abstract:  Zanarini MC. omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study. Am J Psychiatry. 2003 Jan;160(1):167-9.
  39. View Abstract:  Morris CR, et al. Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation. Altern Ther Health Med. Aug2009;15(4):34-43
  40. View Abstract:  Holm T, et al. Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients. Transplantation. Aug2001;72(4):706-11.
  41. View Abstract:  Yam D, Peled A, Shinitzky M. Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemother Pharmacol. 2001;47(1):34-40.
This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.
©2000-2009 CCG, Inc. All Rights Reserved.
Related Articles
- Fatty Acid For Eliminating Acne
Getting sufficient essential fatty acids is of prime importance in clearing acne. Eating essential fatty acids are necessary to provide you the right oils that are used in the sebaceous glands.
- Omega-3 Fatty Acid
- Essential Fatty Acids
- Understanding Essential Fat
- Omega-3 and -6.
- Fatty Acids and Developmental Coordination Disorder
- Heart Protection With Omega-3 Fatty Acids
- Omega 3 Fish Oils
- How To Balance Your Diet with Flax Seed Oil
- Essential Fatty Acids
Regional Articles
- Omega-3 Fatty Acids Alabama
- Omega-3 Fatty Acids Alaska
- Omega-3 Fatty Acids Arizona
- Omega-3 Fatty Acids Arkansas
- Omega-3 Fatty Acids California
- Omega-3 Fatty Acids Colorado
- Omega-3 Fatty Acids Connecticut
- Omega-3 Fatty Acids DC
- Omega-3 Fatty Acids Delaware
- Omega-3 Fatty Acids Florida
- Omega-3 Fatty Acids Georgia
- Omega-3 Fatty Acids Hawaii
- Omega-3 Fatty Acids Idaho
- Omega-3 Fatty Acids Illinois
- Omega-3 Fatty Acids Indiana
- Omega-3 Fatty Acids Iowa
- Omega-3 Fatty Acids Kansas
- Omega-3 Fatty Acids Kentucky
- Omega-3 Fatty Acids Louisiana
- Omega-3 Fatty Acids Maine
- Omega-3 Fatty Acids Maryland
- Omega-3 Fatty Acids Massachusetts
- Omega-3 Fatty Acids Michigan
- Omega-3 Fatty Acids Minnesota
- Omega-3 Fatty Acids Mississippi
- Omega-3 Fatty Acids Missouri
- Omega-3 Fatty Acids Montana
- Omega-3 Fatty Acids Nebraska
- Omega-3 Fatty Acids Nevada
- Omega-3 Fatty Acids New Hampshire
- Omega-3 Fatty Acids New Jersey
- Omega-3 Fatty Acids New Mexico
- Omega-3 Fatty Acids New York
- Omega-3 Fatty Acids North Carolina
- Omega-3 Fatty Acids North Dakota
- Omega-3 Fatty Acids Ohio
- Omega-3 Fatty Acids Oklahoma
- Omega-3 Fatty Acids Oregon
- Omega-3 Fatty Acids Pennsylvania
- Omega-3 Fatty Acids Rhode Island
- Omega-3 Fatty Acids South Carolina
- Omega-3 Fatty Acids South Dakota
- Omega-3 Fatty Acids Tennessee
- Omega-3 Fatty Acids Texas
- Omega-3 Fatty Acids Utah
- Omega-3 Fatty Acids Vermont
- Omega-3 Fatty Acids Virginia
- Omega-3 Fatty Acids Washington
- Omega-3 Fatty Acids West Virginia
- Omega-3 Fatty Acids Wisconsin
- Omega-3 Fatty Acids Wyoming
Related Articles
- Fatty Acid For Eliminating Acne
Getting sufficient essential fatty acids is of prime importance in clearing acne. Eating essential fatty acids are necessary to provide you the right oils that are used in the sebaceous glands.
- Omega-3 Fatty Acid
- Essential Fatty Acids
- Understanding Essential Fat
- Omega-3 and -6.
- Fatty Acids and Developmental Coordination Disorder
- Heart Protection With Omega-3 Fatty Acids
- Omega 3 Fish Oils
- How To Balance Your Diet with Flax Seed Oil
- Essential Fatty Acids
Rate Article
     
Articles Insider

Rss   Delicious   Digg   Add To My Yahoo   Add To My Google   Bookmark   Search Plugin

Topics:
Advertising Family Home Services Real Estate Resources
Business Services Fashion Industrial Goods & Services Retail & Consumer Services
Career Financial Services Insurance Software
Cars Food & Beverage Internet Technology
Computer Hardware Franchise Legal Telecommunications
Construction Health Miscellaneous Trade Shows
Education Holidays Nightlife Travel
Entertainment Home Appliances Online Database Weddings
Environmental Home Electronics Pets World History