Qi Bao Mei Ran Dan

Anticoagulation effect: The anticoagulation effect of the formula's ethanol extract is experimentally demonstrated as follows: The formula prolongs the bleeding time and clotting time in rabbits, reducing the platelet count and its adhesive capability, and prolonging platelet factor I, IV time; the formula also prolongs plasma prothrombin time, prothrombin consumption time and recalcification time, although the differences are not significant; the formula prolongs clot retraction time, increases red cell sedimentation rate, decreases packed cell volume; and finally, the plasma protamine anti-agglutination test is positive.(3)

Anti-hypoxic and anti-anemic effects: Fed to mice and rats for 15 days, this formula can significantly raise the subject's tolerance level for hypoxia, increase the hemoglobin and serum iron levels in rats, and increase catalase activity in mice.(4)

Enhancing adrenal cortical function: Experiments show that at 6g/kg or 12g/kg, the formula can increase the wet weight of the adrenal gland, significantly decrease the vitamin C level in the adrenal gland, and increase the glycogen level in the liver. The formula is effective in enhancing the adrenal cortical function of yang-deficient animals.(5)

Menopausal syndrome
One study treated menopausal syndrome with a modification of Qi Bao Mei Ran Dan, and reported satisfactory results.(7)

Male infertility
A modification of Qi Bai Mei Ran Dan was used to treat 36 cases of male infertility due to unliquefied semen. The basic prescription consisted of Chuan Niu Xi (Cyathulae), processed He Shou Wu (Fleece-flowered Root), Bu Gu Zhi (Psoralea), Gou Qi Zi (Lycium Fruit), Tu Si Zi (Cuscuta), Fu Ling (Hoelen), Dang Gui (Dang Gui), Shu Di Huang (cooked Rehmannia), and Rou Gui (Cinnamon Bark). For lassitude in the loin and legs, Du Zhong (Eucommia) and Sang Ji Sheng (Loranthus) were added. For vexation with mouth dryness, Zhi Mu (Anemarrhena) and Huang Bo (Phellodendron) were added. Sexual activities were avoided while under treatment. The treatment lasted 20-30 days, and had these results: 22 cases were resolved, 6 cases improved, and 8 cases had no effect.(8)

Another study treated 35 cases of male infertility with a modification of Qi Bao Mei Ran Dan, and reported that 22 cases significantly improved, 8 cases improved, and 5 cases did not respond to the treatment.(9)

Aplastic anemia
Qi Bao Mei Ran Dan was used to treat 38 cases of aplastice anemia. For yin-deficient patients the following herbs were added: Xuan Shen (Scrophularia), Mai Dong (Ophiopogon Root), Sang Shen (Mulberry), Can Shan (Excrementum Bombycis), Shan Zhu Yu (Cornus), Wu Mei (Mume), Zhi Zi (Gardenia), Du Zhong (Eucommia), and Zong Lu (Fortune Windmillpalm). For those with yang-deficiency, the following herbs were added: Xian Mao (Curculigo), Rou Cong Rong (Cistanche), Ba Ji Tian (Mroinda), Yin Yang Huo (Epimedium), Fu Zi (Aconite), and Lu Rong (Hairy Antler). For deficiency in both yin and yang, the following were added: Xiao Hui Xiang (Fennel Fruit), Xu Duan (Dipsacus), Huang Jing (Polygonatum Root), and Shan Yao (Dioscorea). One dose of the formula in decoction was administered daily, and one course of treatment lasted 30 days. The results: after 3 courses of treatment, 17 cases were basically resolved, 11 cases entered remission, 17 cases improved, and 3 cases did not respond to the treatment. A follow-up survey spanning 2-18 years found that 13 cases were resolved, 13 cases entered remission, 9 cases improved, and the remaining 3 cases did not respond to the treatment.(10)

Chronic persisting hepatitis
32 cases of chronic persisting hepatitis were treated with this formula. After 2-3 months of treatment, 14 cases were resolved, 3 cases improved, 5 cases had no effect. A one-year follow-up found that 3 cases had relapses but were eventually resolved after using this formula again.(11)