Qing DaiIndigo Naturalis, Natural Indigo
| Dosage |
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For oral usage, it is decocted with 2-5g, wrapped up, or powdered,1.5-6g each time.
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| Toxicity |
One-time administration of indigo at 32g/kg to mice by endogastric infusion does not result in death; neither does one-time administration of indirubin at 25g/kg. The median lethal dose (LD50), when administrated by stomach, did not cause animal death. Their LD 50 (mice/intraperitoneal injection): 2.20 ± 0.23g/kg (indigo), and 1.11 ± 0.23g/kg (indirubin).( 1),( 2),( 3),( 4) |
| Chemical Composition |
Indirubin;
Indigo;
Isoindigo;
Laccerol;
Indican;
Isatan B;
Tryptanthrine;
Qingdainone;
N-nonacosane;
N-phenyl-2-naphthylamine;
b-sitosterol.( 5),( 6),( 7),( 8),( 9)
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| Precautions |
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Patients suffering from deficiency cold in the spleen and stomach should use with caution.
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| Pharmacology |
Qing Dai's component, Indirubin, has anti-tumor effects. The tween suspension of indirubin was administered to rats with tumor (200mg/kg.d) for 6-10 consecutive days by the following three methods: subcutaneous injection, intraperitoneal injection, and by endogastric infusion. The inhibition rates on solid carcinoma in W 256 rats for the above methods of administration were 47%-52%, 50-58%, and 55.7%, respectively. Subcutaneously injected at 200mg/kg, twice daily, indirubin can prolong the survival time of ascitic type W 256 rats. Administered by endogastric infusion at 500mg/kg daily for 9-10 consecutive days, it can inhibit mouse Lewis lung cancer with the inhibition rate of 43%. It also has a moderate inhibitory effect on mammary cancer and sarcoma S 180 in mice. There are also reports that Qing Dai can prolong by about 20% the survival time of lymphocytic leukemia L 1210.( 10),( 11),( 12),( 13) Qing Dai decoction has inhibitory effects on Staphylococcus aureus, anthrax bacillus, Shiga's bacillus and Vibrio comma, etc. Tryptanthrin, an active component of Qing Dai, has strong inhibitory effects on seven kinds of bacteria: Microsporum, Trichophyton tonsurans, Microsporum gypseum, purple trichophyton, red trichophyton, Trichophyton gypseum, Epidermophyton floccosum, etc.( 14) Administered to mice by endogastric infusion stomach at 0.3-3g/kg daily for 8 consecutive days, Qing Dai suspension can protect the subjects from CCl 4-induced hepatic injuries.( 15) |
References
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