Shan Zhu Yu

Shan Zhu Yu can significantly inhibit the functions of the mononuclear phagocyte system in mice. It can suppress in-vitro lymphocyte mitosis reaction and ...

Shan Zhu Yu
Corni Fructus, Cornus
Dosage
Decoction 5~10g, or pill, or powder.
Toxicity
LD50 (mice/intraperitoneal injection): 59.84g/kg (kern of Shan Zhu Yu), and 86.24g/kg (sarcocarp of Shan Zhu Yu).(1)
Chemical Composition
Cornuside; Morroniside; Loganin; Sweroside; Glucose; Fructose; Sucrose; Ursolic acid; Gallic acid; Malic acid; Tartaric acid; Vitamin A; Vitamin B1; Vitamin C; Cornus-tannin 1, 2, 3; Isoterchebin; Tellimagradin II; Tellimagradin I; Cornusiin A,B,C,G; Eugeniin; Gemin; Flavone; Anthraquinone; Sterol; Lactone; Coumarin; Isobutylalcohol; Butanol; Isoamyl alcohol; Linalool oxide; Furfural; b-phenyl ethylalcohol Lemicin; Methyl eugenol; Isoasarone; Ethyl palmitate; Ethyl oleate; Ethyl linoleate; Benzylcinnamate; Palmitic acid; Stearic acid; Copaene; a-terpineol; a-curcumene; Anethole; Asaricin; Aristolone; Ethyl vanillin; Ethyl linolenate; Pulegone; Safrole; Threonine; Valine; Leucine; Isoleucine; Phenylalanine; Histidine; Lysine; Serine; Glutamic acid; Glycine; Alanine; Tyrosine; Arginine; Aspartic acid; Methionine; Proline; Cystine; Linoleic acid; Oleic acid; Palmitic acid; Stearic acid; Linolenic acid; Lauric acid; G,2,3-di-O-galloyl-a-D-glucose; 7-O-methyl morroniside; 1,2,3-tri-O-galloyl-a-glucose; 1,2,6-tri-0-galloyl-a-D-glucose; 1,2,3,6-tetra-O-gal1oyl-a-D-glucose; 4-methoxy-1, 2-benzodioxole.(2)
Inorganic Chemicals
Fe, Al, Cu, Zn, B, P.
Precautions
Patients suffering hyperactive kidney-yang, chronic dampness, and stranguria should avoid using the herb.
Pharmacology
Shan Zhu Yu can significantly inhibit the functions of the mononuclear phagocyte system in mice.(3) It can suppress in-vitro lymphocyte mitosis reaction and mixed lymphocyte reaction. At the dosage 3mg/ml, it can suppress over 80% of the reactions. Oral administration of Shan Zhu Yu decoction decreases lymphocytes production of IL-2in mice.(4)
Use of Shan Zhu Yu for extended periods of time can increase hemoglobin concentration, increase body strength in mice, counteract fatigue, improve tolerance of oxygen deprivation, and enhance memory.(5) Shan Zhu Yu has relatively strong anti-oxidation effects. In one experiment, Zhang used D-galactose to induce senescence in rats, and fed the subjects with Shan Zhu Yu decoction. Six weeks later, it was observed that the SOD activity in the mice's myocardium was increased.(6)
Administered at the dosages of 1.00, 0.5, 0.25g/kg and 4.0, 2.0g/kg, cornin can inhibit carrageenin-induced toe swelling in rats and mice (P<0.01,0.05). At the dosages of 0.6 and 0.3g/kg, it can suppress toe swelling in rats and mice caused by delayed hypersensitivity initiator (P<0.01,0.05); at 15g/kg, continuous use of the herb for 12 days can suppress recurrent swelling and hind-leg swelling (P<0.01, P<0.05). The effect appears to be dosage-dependent.(7)
Administered at the dosage of 1.0mg/kg to rabbits of modeled severe hemorrhagic shock by intravenous injection, loganin, an active ingredient of Shan Zhu Yu, can raise the blood pressure.(8)
Administered by IV injection to healthy rabbits at the dosages of 1.0 or 0.5g/kg, alcohol-based extract of Shan Zhu Yu can suppress platelet aggregation and decrease blood viscosity.(9)
Although Shan Zhu Yu's alcohol-based extract does not seem to affect the blood sugar level in healthy rats, it tends to lower the blood sugar level in healthy mice. Administered at 7g/kg to rats of diabetes induced by tetraoxypyrimidine and adrenaline for 7 days, it can significantly lower the subjects' blood sugar level.(10)
Administered to cats at 2-8g/kg by IV injection, Shan Zhu Yu can: 1) strengthen the myocardium contraction, 2) raise the cardiac efficiency, 3) dilate peripheral blood vessels, 4) strengthen the heart's blood-pumping function, and 5) raise the blood pressure.(11)
Experiments show that Shan Zhu Yu can inhibit the growth of Staphylococcus aureus and Bacillus dysenteriae.(12)
References
  1. Yi Sheng Fu. Journal of Chinese Patented Medicine. 1991;13(3):45.
  2. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  3. Gong Hai Yang, et al. Journal of Pharmacology and Clinical Application of TCM. 1995;11(2):30-33.
  4. Li Jie, et al. Journal of Sino-Japanese Friendship Hospital. 1996;10(1):43-45.
  5. Zang Lian Bi, et al. Journal of Zhejiang College of TCM. 1993;17(5):34.
  6. Zhang Peng Xia, et al. Heilongjian Journal of Medicine and Pharmacology. 1999;22(4):5.
  7. Zhao Shi Ping, et al. Journal of Sino-Japanese Friendship Hospital. 1996;10(4):295-298.
  8. Wang Tian Shan, et al. Journal of Nanjin University of TCM. 1999;15(6):345-346.
  9. Liu Bao Lin, et al. Journal of University of Pharmacology of China. 1992;23(1):19-21.
  10. Jiang Yu, et al. Journal of Pharmacology and Clinical Application of TCM. 1989;5(1):36-38.
  11. Hu Xiao Ying, et al. Journal of Nanjing College of TCM. 1988;(3):28-29.
  12. Shang Sui Cun, et al. Henan Journal of TCM Pharmacy. 1994;(6):21-22.
This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.
©2000-2008 ADCCG, Inc. All Rights Reserved.
Related Articles
- Jian Pi Yin
According to traditional Chinese medicine, Jian Pi Yin strengthens the spleen, induces appetite and digestion, and terminates diarrhea.
- Chuan Shan Jia
- Zi Shan Chun
- Jia Kang Ling Pian
- Zhi Shi
- Fu Yuan Huo Xue
- Qian Lie Shu Wan
- Shan Zha
- Hypothyroidism
- Shan Yao
Related Articles
- Zi Shan Chun
Zi Shan Chun is mainly used to treat refractory ovarian cancer and metastatic breast cancer.
- Zhi Shi
- Fu Yuan Huo Xue
- Shan Zha
- Jian Pi Yin
- Qian Lie Shu Wan
- Hypothyroidism
- Shan Yao
- Chuan Shan Jia
- Jia Kang Ling Pian

Rss   Delicious   Digg   Add To My Yahoo   Add To My Google   Bookmark   Search Plugin

Topics:
Advertising Family Home Services Real Estate Resources
Business Services Fashion Industrial Goods & Services Retail & Consumer Services
Career Financial Services Insurance Software
Cars Food & Beverage Internet Technology
Computer Hardware Franchise Legal Telecommunications
Construction Health Miscellaneous Trade Shows
Education Holidays Nightlife Travel
Entertainment Home Appliances Online Database Weddings
Environmental Home Electronics Pets World History