Treatment on liver cirrhosis
30 cases of cirrhosis of the liver were treated with Shen Ling Bai Shu San with some additional ingredients. For stagnation of
qi, the following herbs were added, Zhi Qiao (Aurantium Fruit), Chuan Lian Zi (Melia), Yuan Hu (Corydalis Tuber), and Chao Mai Ya (cooked Malt). For stagnation and retention of the damp type, the herbs added were Da Fu Pi (Areca Peel), Ze Xie (Alisma), Ze Lian (Lycopus), and Gui Zhi (Cinnamon Twig). For stagnation of
qi and blood stasis type, Bie Jia (Tortoise Plastron), Chuan Shan Jia (Anteater Scales), Ze Lian (Lycopus), and Dan Shen (Salvia) were added. In cases of
yin deficiency of the liver and kidney, Tian Dong (Asparagus), Gou Qi Zi (Lycium Fruit), Chan Yi (Cicada), and Zheng Huang Jing (steamed Ploygonatum Root) were added. Western drugs were used in combination for symptomatic relief. The results showed that 9 cases fully recovered, 14 cases improved, 3 cases had no effectiveness, and 4 cases aggravated.(
6)
Treatment on superficial gastritis
32 cases of superficial gastritis were treated with modified Shen Ling Bai Zhu San. The basic formula consisted of Ren Shen (Ginseng), Bai Zhu (Atractylodes), Fu Ling (Hoelen), Huai Shan Yao (Huai Dioscorea), Gan Cao (Licorice), Bai Shao (White Peony Root), Yuan Hu (Corydalis Tuber), Bian Dou (Dolichos), Yi Ren (Coix), Sha Ren (Amomum Fruit), Ying Su Ke (Opium Poppy Pericarp), and Bai Ji (Bletilla Tuber). The formula was modified according to individuals' symptoms. For accumulation of cold pathogen, Wu Zhu Yu (Evodia) and Gao Liang Jiang (Galanga) were added. For excessive gastric heat, Chai Hu (Bupleurum), Huang Qin (Scutellaria), and Huang Liang (Coptis) were added. In cases of qi stagnancy Chai Hu (Bupleurum) and Xiang Fu (Cyperus) were added. In cases of cold insufficiency type Fu Zi (Aconite) and Gui Zhi (Cinnamon Twig) were added. In situations of stagnancy of food Shen Qu (Leaven), Shan Zha (Crataegus), and Mai Ya (Malt) were added. In case of blood stagnancy Dan Shen (Salvia), Mo Yao (Myrhh), and E Zhu (Zedoaria) were added. The results illustrated that 15 cases clinically recovered, 9 cases had significant improvement, 7 cases had some improvement, and 1 case had no improvement.(7)
Treatment on chronic diarrhea
36 cases of chronic diarrhea were treated with Shen Ling Bai Shu Tang with additional modifications to the ingredients according to individuals' symptoms. After 1 to 2 months of therapy, 28 cases had fully recovered, 6 cases showed significant improvement, and 2 cases had some improvement.(8)
Treatment on chronic colitis
58 cases of chronic colitis of spleen deficiency combined with dampness type were treated with Shen Ling Bai Shu San. The formula was modified according to each individual's symptoms. One tablet of Metronidazole 0.4g twice a day and 2 capsules of Da Suan (Garlic) oil, three times a day were used in combination. The results showed that 42 cases had fully recovered (72.4%), 14 cases had improved (24.1%), and 2 cases had no effect (3.5%).(9)
Treatment on irritable colon
52 cases of irritable colon were treated with modified Shen Ling Bai Zhu San. The total effectiveness rate was 96.2%.(10)
Treatment on periodic paralysis
40 cases of periodic paralysis were treated with Shen Ling Bai Zhu San with some additional modifications according to patients' symptoms. The results provided that 40 cases had diminished symptoms within 3 to 5 days and 10 cases had fully recovered within 1 week. There was no recurrence in 30 cases within one year.(11)
Treatment on functional edema
50 cases of functional edema were treated with Shen Ling Bai Zhu San. 42 cases fully had recovered, 5 cases had improved, and 3 cases had no improvement.(12)
Treatment on chronic ulcerative colitis
Modified Shen Ling Bai Zhu San was used to treat 38 cases of chronic ulcerative colitis. The formula consisted of the following herbs: Dang Shen (Codonopsis), Bai Zhu (Atractylodes), Huang Qi (Astragalus Root), Fu Ling (Hoelen), Shan Yao (Dioscorea), Yi Ren (Coix), Chen Pi (Citrus), Zhi Gan Cao (processed Licorice), Bai Bian Dou (Dolichos), and Sha Ren (Amomum Fruit). For severe spleen insufficiency, the amount of Huang Qi (Astragalus Root) was increased and Pao Jiang (processed Ginger), Wu Zhu Yu (Evodia), and Lian Zi (Hindu Lotus Seed) were added. For spleen and kidney yang insufficiency, Fu Zi (Aconite), Bu Gu Zhi (Psoralea), and Rou Dou Kou (Common Nutmeg Seed) were added. For hyperactivity of the liver combined with spleen deficiency, Chao Bai Shao (cooked White Peony Root), Fang Feng (Siler), and Mu Xiang (Saussurea) were added. In cases of spleen deficiency combined with damp heat, Bai Tou Weng (Pulsatilla Root), Qin Pi (Fraxinus), and Di Yu (Sanguisorba) were added. For retention of fluid pathogen in intestine, Yi Ren (Coix) was replaced with Chao Yi Ren (cooked Coix), Gui Zhi (Cinnamon Twig), and Ze Xie (Alisma). After treatment, 28 cases had fully recovered, 8 cases had improved, and 2 cases had no effectiveness. The total effectiveness rate was 94.7%.(13)
Treatment on chronic pharyngitis
Shen Ling Bai Zhu San was used to treat 60 cases of chronic pharyngitis. The formula was modified according to individuals' symptoms. After treatment of 1 to 5 courses, the results were: 57 cases fully recovered, 2 cases improved, and 1 case had no known effect. The total effectiveness rate was 98.3%.(14)
Treatment on central serous retinochoroiditis
Shen Ling Bai Zhu San was used to treat 56 cases of retinochoroiditis. The formula was modified according to the patients' symptoms. The total effectiveness rate was 94.6%. Visual acuity of the diseased eyes improved markedly.(15)
Treatment on Pediatric diseases
Shen Ling Bai Zhu San was used to treat pediatric diseases such as diarrhea, infantile malnutrition, poor appetite, recurrent asthma, and recurrent upper respiratory tract infections. Among the 86 cases of diarrhea, 79 cases fully recovered, and 2 cases improved. Among the 27 cases of infantile malnutrition, 20 cases fully recovered, 4 cases showed significant improvement, 3 cases had some improvement, and 1 case had no effectiveness. Among the 31 cases of asthma, 27 cases fully recovered, 2 cases showed significant effectiveness, and 2 cases had some improvement. Among the 37 cases of upper respiratory infection, 32 cases fully recovered, 3 cases had a significant improvement, and 32 cases had some improvement.(16)
Treatment on toxic and other side effect of chemotherapy
Shen Ling Bai Zhu Tang was used to treat 40 cases of indigestion that occurred after chemotherapy for malignant tumors. The total effectiveness rate was 90.2%.(17) Shen Ling Bai Shu Sang was combined with Metronidazole and noticeably reduced the toxic side effects of chemotherapy as well as increased the tolerance of chemotherapy.(18)
Others
Shen Ling Bai Zhu San had been used to treat hyperlipidemia,(19) sequel of apoplexia,(20) chronic delayed type rectitis,(21) pityriasis,(22) chronic sinusitis,(23) oral mucus membrane diseases,(24) impotence,(25) immunologic hypofunction,(26) and iron deficiency anemia of children.(27) There has been some effectiveness.