Vitamin D

Vitamin D is known as the "sunshine" vitamin because it is formed in the body by the action of the sun's ultraviolet rays on the skin.

Vitamin D - Dietary Supplements
Calciferol
Natural Health Information that is accurate, objective, science-based and represents the current state of research is the most sought-after information category today. Natural Health Information On Demand, NHIOndemand, is the leading source for this valuable science-based natural health information.
©2000-2009 CCG, Inc. All Rights Reserved.
Introduction
Vitamin D is known as the "sunshine" vitamin because it is formed in the body by the action of the sun's ultraviolet rays on the skin. The fat-soluble vitamin is converted in the kidneys to the hormone calcitrol, which is actually the most active form of vitamin D. The effects of this hormone are targeted at the intestines and bones.
Dosage Info
Dosage Range
Dosages that have been used in clinical studies range from 200IU (5mcg) to 10,000IU (250mcg) daily.(1),(2) The American Academy of Pediatrics has increased the recommeded 200IU minimum daily intake of vitamin D to a minimum of 400IU/day.(3It is important to note that based on the presence of hypercalcemia (2.75mmol/L or 11mg/dL) at a given dose, The Food and Nutrition Board of the National Academy of Sciences states that 95 mcg of vitamin D per day is the lowest observed adverse effect level reported.(4)
Most Common Dosage
400IU (10mcg) daily.

40IU = 1mcg

Dosage Forms
Capsules, tablets, and liquid.
Interactions and Depletions
Depletions
Reported Uses
Vitamin D is important for the growth and development of bones and teeth.(5) For this reason, vitamin D is an important growth nutrient for infants and children. Vitamin D supplementation in early pregnancy may prevent preeclampsia and promote neonatal well-being.(6) Vitamin D is one of the primary regulators of calcium absorption, which is also important for proper bone health and development. Deficiencies are frequently found in individuals with or at risk for osteoporosis.(7),(8),(9),(10),(11) Considering this relationship, vitamin D insufficiency may have an effect on bone strength.(12),(13) Demineralization is ocurring in children who are vitamin D deficient.(14)

Vitamin D is perhaps best known as a treatment for the disease associated with vitamin D deficiency, rickets.(15) Researchers found that vitamin D deficiency increased risk of mortality for men and women.(16) Studies have indicated that a higher intake of vitamin D could lower the risk of breast cancer in women.(17),(18) Sun-induced vitamin D has shown benefits in colon, lung, breast and prostate cancer.(19) Vitamin D may be associated with improved survival after diagnosis of colorectal cancer.(20),(21) Deficiency has also been linked to Parkinson's disease, Crohn's disease and hearing loss.(22),(23),(24) Vitamin D was found to boost the immune system of subjects, thereby, protecting the brain from Alzheimer's disease.(25)

Supplementation may treat skin disorders such as psoriasis and scleroderma.(26),(27) Finally, supplementation may be necessary for epileptics, as medications to treat the disorder may deplete vitamin D.(28) Two studies found vitamin D deficiency in young people is associated with an increased incidence of risk factors for cardiovascular problems such as heart attack and stroke.(29),(30)

Researchers found that vitamin D supplementation in children may reduce the risk of developing type 1 diabetes later in life.(31) Vitamin D from ultraviolet B rays reduced the risk of type 1 diabetes in children.(32) Results of a study revealed vitamin D deficiencies and was concluded that children not getting enough vitamin D through their diet should take a vitamin D supplement of 400IU daily.(33) Vitamin D supplementation during pregnancy and early childhood may reduce the risk of a child developing multiple sclerosis later in life.(34)

Toxicities & Precautions
Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.
Introduction
Be sure to tell your pharmacist, doctor or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.
General
Vitamin D can be toxic,(35) but this dietary supplement is considered safe when used in accordance with proper dosing guidelines.
Side Effects
Occasional side effects reported with large doses of this dietary supplement include a disorder known as hypercalcemia,(36) which causes calcium deposits in soft tissues. Signs of the disorder include headache, weakness, nausea, vomiting, and constipation. It may be necessary to reduce the dose of this dietary supplement. Consult a physician before using vitamin D in large doses. Tell your physician if these side effects become severe or do not go away.
Pregnancy/Breast-Feeding
To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Proper nutrition is essential during pregnancy for the healthy development of the fetus. Numerous vitamins and minerals are a vital part of proper nutrition. If you are pregnant, think you might be pregnant, trying to get pregnant, or breast-feeding an infant, talk to your healthcare professional about supplementing your diet with appropriate vitamins and minerals.
Age Limitations
To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Vitamins and minerals are an essential part of proper growth and development. Talk to your healthcare professional about the appropriate use of vitamins and minerals in children. Do not use any vitamin or mineral in children under 2 years of age unless first discussed with your healthcare professional.
Links

Content provided by NHI OnDemand, the trusted online source of current natural health & wellness information.

References
  1. View Abstract:  Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. May1999;69(5):825-6.
  2. View Abstract:  Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. Feb2001;73(2):288-94.
  3. View Abstract:  Wagner CL, et al. Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents. Pediatrics. Nov2008;122(5):1142-1152
  4. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride; Washington, DC: National Academy Press; 1999:282. Book available at: http://books.nap.edu/books/0309063507/html/index.html.
  5. View Abstract:  Outila TA, Karkkainen MU, Lamberg-Allardt CJ. Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am J Clin Nutr. Aug2001;74(2):206-10.
  6. View Abstract:  Bodnar LM, et al. Maternal vitamin d deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. Sep2007;
  7. View Abstract:  Villareal DT, et al. Subclinical Vitamin D Deficiency in Postmenopausal Women with Low Vertebral Bone Mass. Journal of Clinical Endocrinology and Metabolism. 1991;72(3):628-34.
  8. View Abstract:  Rassouli A, Milanian I, Moslemi-Zadeh M. Determination of serum 25-hydroxyvitamin D(3) levels in early postmenopausal Iranian women: relationship with bone mineral density. Bone. Nov2001;29(5):428-30.
  9. View Abstract:  Mezquita-Raya P, Munoz-Torres M, Luna JD, et al. Relation between vitamin D insufficiency, bone density, and bone metabolism in healthy postmenopausal women. J Bone Miner Res. Aug2001;16(8):1408-15.
  10. View Abstract:  Brot C, Vestergaard P, Kolthoff N, Gram J, Hermann AP, Sorensen OH. Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. Br J Nutr. Aug2001;86(Suppl 1):S97-103.
  11. View Abstract:  Grados F, et al. Prediction of bone mass density variation by bone remodeling markers in postmenopausal women with vitamin D insufficiency treated with calcium and vitamin D supplementation. J Clin Endocrinol Metab. 2003 Nov;88(11):5175-9.
  12. View Abstract:  Mezquita Raya P, Munoz Torres M, Lopez Rodriguez F, et al. Prevalence of vitamin D deficiency in populations at risk for osteoporosis: impact on bone integrity. Med Clin (Barc). Jun2002;119(3):85-9.
  13. View Abstract:  Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. Mar2003;326(7387):469.
  14. View Abstract:  Gordon CM, et al. Prevalence of Vitamin D Deficiency Among Healthy Infants and Toddlers. . Arch Pediatr Adolesc Med. Jun2008;162(6):505-512
  15. View Abstract:  Takeda E, et al. Vitamin D-dependent Rickets Type I and Type II. Acta Paediatr Jpn. Aug1997;39(4):508-13.
  16. View Abstract:  Melamed ML, et al. 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. Aug2008;168(15):1629-37
  17. View Abstract:  Lin J, et al. Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women. Archives of Internal Medicine. May2007;167(10):1050-59
  18. View Abstract:  Mohr SB, et al. Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries. Breast J. May2008;14(3):255-60
  19. View Abstract:  Moan J, et al. Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure. Pro Natl Acad Sci. Jan2008.
  20. View Abstract:  Ng K, et al. Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer. Aug2009
  21. View Abstract:  Fedirko V, et al. Effects of vitamin d and calcium on proliferation and differentiation in normal colon mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers and Prevention. Nov2009;18(11):2933-41
  22. View Abstract:  Evatt ML, et al. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. Oct2008;65(10):1348-52
  23. View Abstract:  Andreassen H, et al. Regulators of Calcium Homeostasis and Bone Mineral Density in Patients with Crohn's Disease. Scand J Gastroenterol. Oct1998;33(10):1087-93.
  24. View Abstract:  Brookes GB. Vitamin D Deficiency and Deafness: 1984 Update. Am J Otol. Jan1985;6(1):102-07.
  25. View Abstract:  Masoumi A, et al. 1alpha,25-dihydroxyvitamin D formula 3 formula Interacts with Curcuminoids to Stimulate Amyloid-beta Clearance by Macrophages of Alzheimer's Disease Patients. J Alzheimers Dis. 2009;17(3):703-717
  26. View Abstract:  Morimoto S, et al. Inverse Relation Between Severity of Psoriasis and Serum 1,25-dihydroxy-vitamin D Level. J Dermatol Sci. Jul1990;1(4):277-82.
  27. View Abstract:  Humbert P, et al. Treatment of Scleroderma with Oral 1,25-dihydroxyvitamin D3: Evaluation of Skin Involvement Using Non-invasive Techniques. Results of an Open Prospective Trial. Acta Derm Venereol. Dec1993;73(6):449-51.
  28. View Abstract:  Shafer RB, et al. Calcium and Folic Acid Absorption in Patients Taking Anticonvulsant Drugs. J Clin Endocrinol Metab. Dec1975;41(06):1125-29.
  29. View Abstract:  Kumar J, et al. Prevalence and Associations of 25 Hydroxyvitamin D Deficiency in US Children: NHANES 2001 to 2004. Pediatrics. Aug2009
  30. View Abstract:  Reis JP, et al. Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population. Pediatrics. Aug2009
  31. View Abstract:  Zipitis CS, et al. Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis. Arch Dis Child. Mar2008.
  32. View Abstract:  Mohr SB, et al. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. Jun2008
  33. View Abstract:  Svoren BM, et al. Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus. Journal of Pediatrics. Jan2009;154(1):132-134
  34. View Abstract:  Ramagopalan SV, et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1 1501 is regulated by vitamin D. PLoS Genet. Feb2009;5(2):1000369
  35. View Abstract:  Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. Aug2008;88(2):582-586
  36. View Abstract:  Selby PL, Davies M, Marks JS. Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate. Clin Endocrinol (Oxf). Nov1995;43(5):531-6.
This information is educational in context and is not to be used to diagnose, treat or cure any disease. Please consult your licensed health care practitioner before using this or any medical information.
©2000-2009 CCG, Inc. All Rights Reserved.
Related Articles
- Vitamin C Skin Care
Vitamin C, also known as ascorbic acid, is an essential nutrient for humans. Ascorbic acid is required for many enzymatic functions in the body and also in the synthesis of collagen. Humans need to regularly consume vitamin to avoid deficiencies. Deficiencies of Vitamin C are very rare in North America.
- Vitamin A
- Information About The Overlooked Vitamin
- Benefits Of Vitamin A
- Vitamins And Their Usefulness
- How to Eat Vitamin D
- Fight Osteoporosis With Vitamin K
- Vitamin C
- Sources Of Vitamin A
- Sources For Vitamin K
Related Articles
- Vitamin A
Vitamin A can be found in animals through retinol and vegetables through carotenes. An important vitamin, it's used for growth, healthy skin and cells, and the linings of the body. It is also important in maintaining good vision.
- Information About The Overlooked Vitamin
- Sources Of Vitamin A
- How to Eat Vitamin D
- Fight Osteoporosis With Vitamin K
- Vitamins And Their Usefulness
- Vitamin C
- Vitamin C Skin Care
- Sources For Vitamin K
- Benefits Of Vitamin A

Rss   Delicious   Digg   Add To My Yahoo   Add To My Google   Bookmark   Search Plugin

Topics:
Advertising Family Home Services Real Estate Resources
Business Services Fashion Industrial Goods & Services Retail & Consumer Services
Career Financial Services Insurance Software
Cars Food & Beverage Internet Technology
Computer Hardware Franchise Legal Telecommunications
Construction Health Miscellaneous Trade Shows
Education Holidays Nightlife Travel
Entertainment Home Appliances Online Database Weddings
Environmental Home Electronics Pets World History