Experiments show at 5.4g/kg, Yi Yi Ren oil can inhibit grafted S 180 sarcoma in mice with an inhibition rate of above 30%. Similarly, at 1.8g/kg and 5.4g/kg, Yi Yi Ren oil can inhibit grafted HAC hepatocarcinoma in mice with an inhibition rate of above 30%. At 1.8g/kg, Yi Yi Ren oil can significantly increase the phagocytic rate of mice's abdominal macrophage against chicken red cells; at 5.4kg/kg, it can enhance the activity of mice's NK cells.( 6) Combined with either cisplatin or mitomycin, Yi Yi Ren total extract can significantly increase the inhibition rate against grafted S 180 and hepatocarcinoma H 22 in mice. Such use can also enhance the activity of NK cells, and protect the subjects from chemical-induced atrophy of immune organshad, from decreases in the macrophage's phagocytic function, and from decreases in white blood cell count.( 7) Dextran 1-7, neutral polysaccharides derived from the herb dextran 1-7, and CA-1 and CA-2, acid polysaccharides derived from the herb, have anti-complementary activities.( 8) Experiments show that coixenolide can significantly enhance immunologic function of red cells in mice with various tumors (e.g., S 180, EAC, and L 615).( 9) Abdominal administration of 75% alcohol-based extract of Yi Yi Ren can inhibit water immersion stress- and hydrochloric acid-induced ulcers in mice. The same treatment can also inhibit senna leaf-induced diarrhea in mice. However, it does not inhibit castor oil-induced diarrhea or gastrointestinal peristalsis in mice. In rats, the treatment mildly promotes bile secretion.( 10) I.g. administration of 75% alcohol-based extract of Yi Yi Ren, at 5 or 10 g/kg, can antagonize dimethylbenzene-induced ear swelling and carrageenin-induced foot swelling in mice. The same treatment can slightly inhibit peritoneal capillary hyperpermeability in mice. Administered to rats at 3 or 10g/kg, it can prolong the thrombosis time and coagulation time caused by stimulating the carotid with electricity.( 11) Moreover, one study treated 26 cases of severe functional dysmenorrhea with Yi Yi Ren, and reported that over 90% of the patients significantly improved, indicating that the herb has an analgesic effect.( 12) Experiments show that feruloyl stigma sterol and eruloyl campesterol, two active components of Yi Yi Ren, can induce ovulation in golden hamsters. Administered to rabbits by subcutaneous injection, Yi Yi Ren oil and fatty acids with more than 12 carbon atoms can decrease the subjects' blood sugar level. Similarly, administered to mice by peritoneal injection, coixan A, B, C can significantly lower the subjects' blood sugar level within 7-24 hours.( 13) |