Ze Xie Rhizoma Alismatis, Alisma
| Toxicity |
LD50: 0.78g/kg (mice/alcohol-based extract/IV); 1.27g/kg (mice/alcohol-based extract/abdominal injection)( 1),( 2) |
| Chemical Composition |
Alisol A, B, C;
Alisol A monoacetate;
Alismol;
Alismoxide;
Epialisol A;
Tricosane;
Stearic acid;
Glyceryl-1-stearate;
Daucosterol-6'-O-stearate;
Alisol B monoacetate;
Emodin;
Alisol C monoacetate.( 3),( 4),( 5)
|
| Pharmacology |
Taking this herb orally by healthy people increases the urine, sodium, and urea output.( 6),( 7),( 8) In experiments on hamsters, the water decoction of this herb significantly lowers the renal calcium content and decreases calcium oxalate crystal formation in the renal tubule, thereby inhibiting the formation of kidney stones.( 9),( 10) Administered to mice at the dosages of 10g/kg and 20g/kg, the water decoction of this herb slows down carbon clearance, and inhibits 2, 4-chloronitrobenzene-induced contact dermatitis.( 11) An Alcohol-based extract of the herb increases isolated rabbit heart's coronary artery blood flow volume, has a slight inhibitory effect on miocardia, but does not affect the heartbeat rate.( 12) In experiments on hamsters, this herb significantly lowers the levels of total cholesterol and LDL-cholesterol in the serum, inhibits blood platelet aggregation and thrombosis, and enhances fibrinolysin activity.( 13) This herb has a significant inhibitory effect on high fat feed-induced fatty liver.( 14) Administering raw herb decoction (20g/kg) to sodium glutamate-fattened hamsters lowers their Lee index, fat indices, and serum nitroglycerine content.( 15) |
References
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